Walking Thoughts

  A transformative new drug for pancreatic cancer.  Pancreatic adenocarcinoma is one of the deadliest cancers, with a five-year survival rate of  just 13 percent ; advances in therapy against the disease have been slow. A key reason is that around  three-quarters  of these cancers are driven by mutations in KRAS, a protein that has been considered essentially undruggable because it lacks an obvious binding site for a drug molecule. A new treatment, called daraxonrasib, gets around this by first binding to another protein in the cell, cyclophilin A, forming a complex that can then  latch onto and block mutant KRAS, cutting off the signal that drives tumor growth.  In a phase three trial of around 500 patients with metastatic pancreatic cancer who had already progressed while on chemotherapy, the company  reported  a median overall survival of 13.2 months with daraxonrasib versus 6.7 months with chemotherapy, roughly doubling survival. That is ...

  Today is the first day of food caddy collection From our ‘doorstep’ by the local council. It seems a little belated and has been divisive. Reading the marketing material that has accompanied this change in waste collection Has brought to mind my first LinkedIn post On Halfway to Net Zero, also published in chemical industry journal  https://www.chemicalindustryjournal.co.uk/on-halfway-to-net-zero . This is because One of the ways in which  Council food caddy schemes provide environmental benefits is diversion of the food waste from landfill, reducing greenhouse gas emissions. The methane which arises is 2800% more potent than CO2, Having a carbon dioxide equivalent (CO2e) of 28. When I responded to claims that the UK were halfway to net zero, I noted that the inroads we had made to date were largely from one offs such as closing the coalmines, banning CFCs and reducing methane emissions from landfill. Not to mention a pandemic. “ It has taken 30 years – and a pandemic –...

  Here’s a sharpened, high-impact LinkedIn piece that keeps your voice but gives it authority, rhythm, and that quiet “this person knows exactly what they’re doing” energy: Hook (stop-the-scroll line): You don’t have to choose between being brilliant on paper and brilliant in practice. I recently had a moment that made me pause. A new line manager described me as  “very academic.” And they’re not wrong. But it isn’t how I see myself. Because here’s the truth: I didn’t become academic  instead of  being practical. I became academic  because  I’m practical. I started out intending to study physics, but quickly pivoted to natural sciences. Not for the title, but for the impact. I wanted a career rooted in environmental protection, not just theory. Three years into the water industry, split between compliance and innovation, I found something that mattered enough to pursue deeply. That’s when I chose to do a PhD in wastewater engineering. Not at the start of my...

  I honestly don’t know whether to be disappointed or pleased with my new line managers take on my skill set. My line manageremphasised the high academic achievement I have. I am academically very strong. But it is not first and foremost how I see myself man by professional skills. I chose an academic course, which aligned with my passions. Having initially set out to do physics at university, I quickly changed to a course in natural sciences life sciences is enabled me to move into a career dedicated to environmental protection. Then I spent three years in the water industry, partly in quality control and compliance, And partly in research and innovation. Here I found sufficient passion to complete a PhD in wastewater engineering for environmental protection. And now I have completed 30 years dedicated to a broad skill set In sustainability, The protection of rivers in nature, The reduction of home home by necessary human activity such as water supply water production and industri...

  That testimonial has a quiet sting in it, doesn’t it? Like finding your fingerprints on a machine that’s now humming along without your name on the casing. The trick here is to bottle the  impact  and let it speak loudly, even if the origin story was whispered. Here are a few polished ways you can translate that into CV and LinkedIn language that feels confident, technical, and unmistakably  yours : Option 1: CV-ready (concise, impact-focused) Originated and led the development of a predictive maintenance framework for pumping station assets, combining engineering insight with data science to create a scalable algorithmic solution. Collaborated with data scientists to translate operational concepts into deployable analytics tools. Embedded methodology into organisational procedures and policy, enabling long-term adoption and establishment of a dedicated delivery function. Delivered a solution that continues to underpin current predictive maintenance approaches, dem...

  Here’s a sharpened, scroll-stopping social media article that keeps your voice but lands with clarity, authority, and just enough edge to make people pause mid-scroll: “He must have eaten too many sweets.” No. Just… no. My child has Type 1 Diabetes. Not because of diet. Not because of parenting. Not because of anything I did or didn’t do. It’s an autoimmune disease. His pancreas doesn’t produce insulin. That’s it. That’s the whole story. And yet— the number of times I’ve been judged, blamed, or quietly assessed as “the mother who caused it”… is astonishing. Let me tell you what people don’t see. When people hear “diabetes”, many picture poor diet and excess weight. But one of the early warning signs of Type 1 is actually being  thinner . Another is  unquenchable thirst . So no— not the stereotype. Not even close. What people  really  don’t understand is what low blood sugar, hypoglycaemia, actually does. It doesn’t just mean “a bit shaky”. It means: • Confusio...